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艾美捷科技代理Vectorbiolabs品牌全系列产品


Vector Biolabs是一家专注于提供高质量AAV(腺相关病毒)和腺病毒产品的生物科技公司,总部位于宾夕法尼亚州费城。Vector Biolabs公司提供包括定制病毒载体生产、载体设计、克隆、扩增、包装、纯化和滴度测定在内的服务,并且拥有一个包含超过90,000种针对人类、小鼠和大鼠基因组定制的AAV产品目录,服务于包括生物制药公司和研究机构在内的全球客户。此外,Vector Biolabs 为研究界提供与基因表达、基因编辑和基因沉默相关的服务。


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Vectorbiolabs公司的产品与服务

AAV定制生产:根据客户需求,定制生产AAV载体,以满足特定的研究或治疗需求。

● AAV控制产品:提供一系列用于AAV基因治疗的控制产品,确保实验的准确性和可靠性。

● 腺病毒建设与扩增:提供腺病毒的构建和扩增服务,支持客户的病毒载体研究。

● shRNA筛选/验证与产品目录:提供shRNA筛选和验证服务,以及相关的产品目录,帮助客户进行基因沉默研究。

使用AAV进行基因治疗的好处:

①低免疫反应:AAV载体引发免疫反应的可能性较低,适合敏感应用。

②稳定的基因递送:提供非整合基因递送,降低诱变风险。

③可扩展的生产:确保从小规模到大规模的研究和临床试验的可靠供应。

④广泛的治疗应用:多功能性使其成为靶向大脑、肝脏和视网膜等器官的理想选择。


特性AAV腺病毒 (Adenovirus)
基因表达长期、稳定表达快速、瞬时表达
免疫原性
装载容量~4.7 kb~8 kb - 38 kb (大得多)
趋向性/靶向能力高 - 可通过不同衣壳定制广泛,可靶向多种组织
最佳应用场景体内研究,长期表达体外 & 体内研究,癌症 & 疫苗研究

Vectorbiolabs部分产品列表


品名货号AAV SerotypeAAV ITRPromoterReporterStorage BufferTiterViral BackboneVolume (µL)
AAV1-LacZ7001AAV1AAV2CMV (ubiquitous)LacZPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV1-GFP7002AAV1AAV2CMV (ubiquitous)eGFPPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV2-LacZ7003AAV2AAV2CMV (ubiquitous)LacZPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV2-GFP7004AAV2AAV2CMV (ubiquitous)eGFPPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV5-LacZ7005AAV5AAV2CMV (ubiquitous)LacZPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV5-GFP7006AAV5AAV2CMV (ubiquitous)eGFPPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV9-GFP7007AAV9AAV2CMV (ubiquitous)eGFPPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV6-GFP7008AAV6AAV2CMV (ubiquitous)eGFPPBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV1-Cre7010AAV1AAV2CMV (ubiquitous)-PBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV2-Cre7011AAV2AAV2CMV (ubiquitous)-PBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV5-Cre7012AAV5AAV2CMV (ubiquitous)-PBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20
AAV6-Cre7013AAV6AAV2CMV (ubiquitous)-PBS/5% Glycerol1x10^13 GC/mlRecombinant AAV20


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艾美捷科技代理Vectorbiolabs品牌全系列产品
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Dendritics.jpg

Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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邮箱:sales@amyjet.com

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