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Dendritics.jpg

Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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艾美捷科技代理ALZET品牌渗透泵产品。

MiTeGen是一家专注于为结构生物学研究提供高质量工具和设备的公司,其产品广泛应用于结构生物学、药物开发、蛋白质工程、材料科学等领域。MiTeGen公司以其创新的样品制备技术和高通量结晶工具闻名。


ALZET是一家专注于研发和生产渗透泵技术的公司,其产品主要用于实验室动物研究中的药物输送和实验试剂释放。ALZET品牌由DURECT Corporation所有,总部位于美国加利福尼亚州。ALZET渗透泵以其精确、持续和可控的药物释放能力,可用于多种动物模型和研究领域,如药理学、毒理学、神经科学等。ALZET的核心产品是渗透泵,这是一种小型植入式设备,能够在预定的时间内以恒定速率释放药物或实验试剂。ALZET渗透泵因其独特的技术优势和广泛的应用场景,已成为实验室研究中不可或缺的工具,尤其在需要精确控制药物释放的研究中表现突出。以下是ALZET的主要产品系列:


(1)ALZET Osmotic Pumps用于小鼠、大鼠和其他实验动物的持续药物输送。

其特点是:

a. 以恒定速率释放药物,避免血药浓度波动。

b. 提供不同容量(如100 µL、200 µL、2 mL等)和释放速率(如0.11 µL/小时至10 µL/小时)。

c. 支持从1天到6周的持续释放。


(2)ALZET Brain Infusion Kits,专为脑部药物输送设计,适用于中枢神经系统研究。

其特点是:

a. 精准输送药物至特定脑区。

b. 兼容ALZET渗透泵,实现持续释放。


(3)ALZET Catheters,用于血管内或腹腔内药物输送。

其特点是:

灵活设计,适用于多种实验需求。

与ALZET渗透泵无缝连接。


(4)ALZET Accessories,包括填充管、植入工具等辅助设备,简化实验操作。


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